Minoflame represents a valuable ally against inflammation and oxidative stress, effectively performing its function of regulating the immune system.

MECHANISM OF ACTION

Curcuma longa is a traditional remedy in folk medicine, whose use and biological activities have been extensively studied by scientific research to validate its ethnopharmacological use. Among the biologically relevant molecules, significant attention has been given to curcumin, a polyphenolic compound belonging to the curcuminoid family. Numerous studies have demonstrated the powerful antioxidant, anti-inflammatory, and immunomodulating actions of this intriguing molecule, whose bioavailability, however, remains very limited. To address this issue, research has focused on studying the pharmacokinetics (ADMET) of the molecule, highlighting how the use of the phytocomplex from C. longa can significantly enhance curcumin’s bioavailability by increasing its absorption at the intestinal level. This enhancement is attributed to other classes of molecules that make up the phytocomplex of the plant, such as volatile compounds. The anti-inflammatory action of curcumin occurs through the modulation of numerous biological targets, including transcription factors, cytokines, proteins, receptors, and pro-inflammatory enzymes, such as the inducible isoform of cyclooxygenase (COX2). Regarding antioxidant action, it has been shown that this molecule can inhibit the production of reactive oxygen species (ROS), also by enhancing the activity of the main antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSHpX).

BIBLIOGRAPHY

● Verma, R. K., Kumari, P., Maurya, R. K., Kumar, V., Verma, R. B., & Singh, R. K. (2018). Medicinal properties of turmeric (Curcuma longa L.): A review. Int. J. Chem. Stud, 6(4), 1354-1357. ● Krup, V., Prakash, L. H., & Harini, A. (2013). Pharmacological activities of turmeric (Curcuma longa Linn): a review. J Homeop Ayurv Med, 2(133), 2167-1206. ● Maheshwari, M. (2010). Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model. Journal of Functional Foods, 2(1), 60-65.